The improved shape medicine which includes substantially the uniform particle of the crystallite characteristic cellulose based shape medicine of granule condition with compressibility and high functionality is offered. This improved shape medicine includes the collapse medicine the crystallite characteristic cellulose and the binder and according to need, is formed by spraying doing the uniform slurry of those components. This shape medicine, high flowability/the flow quality which is superior, the excellence/brings high compressibility, and API is high filling up characteristic and miscibility in comparison with the shape medicine which was formed from the same material in comparison with the individual component, and by former method. This improved shape medicine has connection building a bridge between the powerful particles between the component, considerable openness structure or the unique constructional feature which has the hole where it is dented is brought. With the favor where these holes exist the surface becomes uneven, unevenness of this surface is ideal environment for the improvement of mixture with API.圧縮性かつ高機能性で顆粒状の微結晶性セルロースベース賦形剤の実質的に均一な粒子を含む改良型賦形剤が提供される。この改良型賦形剤は、微結晶性セルロースおよび結合剤ならびに必要に応じて崩壊剤を含み、それらの成分の均一なスラリーを噴霧することによって形成される。この賦形剤は、個別の成分と比べて、および同じ材料から従来の方法によって形成された賦形剤と比べて、高い流動性/優れた流動特性、優秀な/高い圧縮性、ならびにAPIの高い充填性および混和性をもたらす。この改良型賦形剤は、成分間に強力な粒子間結合架橋を有し、かなりの開放性の構造または凹んだ孔を備えた独特の構造的形態がもたらされる。これらの孔が存在するおかげで表面がでこぼこになり、この表面のでこぼこは、APIとの混和の改善にとって理想的な環境である。
