The shape medicine which the crystallite characteristic cellulose based shape medicine of high functional granule condition of compressibility includes the homogeneous particle substantially and is improved is offered. The shape medicine which it describes is improved, the crystallite characteristic cellulose, includes the binder and the collapse medicine, is formed by spraying doing the homogeneous slurry of the above-mentioned component. /The high compatibility where the above-mentioned shape medicine was superior, by comparison with the individual component, by comparison with the former shape medicine which at the same time was formed from the same substance, flowability (flowability)/the satisfactory flow quality which was reinforced, and API load and the miscibility which are increased are offered. The shape medicine which it describes is improved has connecting building a bridge inside the powerful particle between the above-mentioned component, causes peculiar structural form, can list remarkable outer stroke structure or the hollow hole as this form. Existence of these holes offers the roughness of the surface which is ideal environment for mixing to which API is improved.圧縮性の高機能性の顆粒状の微結晶性セルロースベースの賦形剤の実質的に均質な粒子を含む改善された賦形剤が提供される。上記改善された賦形剤は、微結晶性セルロース、結合剤および崩壊剤を含み、上記成分の均質なスラリーを噴霧することによって形成される。上記賦形剤は、個々の成分と比較して、かつ同じ物質から形成された従来の賦形剤と比較して、増強された流動性(flowability)/良好な流動特性、優れた/高い適合性、ならびに増大したAPI負荷および混和性を提供する。上記改善された賦形剤は、上記成分の間で強力な粒子内接合架橋を有し、特有の構造形態を生じ、この形態としては、顕著な開放構造もしくは中空孔が挙げられる。これら孔の存在は、APIとの改善された混和のための理想的な環境である表面の粗さを提供する。
