PROBLEM TO BE SOLVED: To provide a method for producing a tablet that uses citric acid, maintains tablet shape even in transportation, has no problem, does not generate a carbon dioxide gas due to preservation and is entirely dissolved in water in use.SOLUTION: A mechanical fluidized bed granulator which does not substantially use air as a stirring action is utilized, the powder temperature of a mixture of citric acid and a polyethylene glycol is raised to 60-65°C and the mixture is cooled to give a granulated substance A. Similarly, the powder temperature of a mixture of sodium hydrogen carbonate and a polyethylene glycol is raised to 60-65°C, the mixture is cooled to give a granulated substance B. The granulated substance A is mixed with the granulated substance B in a ratio of 1:2 to 1:10 and compression molded to produce tablets.COPYRIGHT: (C)2011,JPO&INPIT【課題】クエン酸を使用した上で、輸送しても錠剤の形状を維持して問題なく、保存による炭酸ガスの発生も無く、使用に際し全部が水に溶解する錠剤の製造方法を提供する。【解決手段】実質的に空気を攪拌作用として使用しない機械式流動層造粒機を使用し、クエン酸とポリエチレングリコールの混合物の粉体温度を60~65℃にあげ、冷却して得た造粒物Aと、同様に炭酸水素ナトリウムとポリエチレングリコールの混合物の粉体温度を60~65℃にあげ、冷却して得た造粒物Bを1対2~1対10の比率で混合し、圧縮成型して錠剤を製造する。【選択図】なし
