A wrist orthosis (1) for support of a patient's wrist, comprising a wire frame (2) for engagement with a forearm (F), wrist (W), and hand (H) of a patient, the wire frame (2) comprising a radial wire section (3) configured to extend in a distal direction along the forearm, wrist and toward a radial side of the hand. The radial wire section (3) is connected to a palmar wire section (4) configured to extend in lateral direction from the radial side of the hand along a palmar region (6) thereof toward an ulnar side of the hand. The palmar wire section (4) is connected to an ulnar wire section (5) configured to extend from the ulnar side of the hand in proximal direction toward an along the wrist and forearm. The radial and ulnar wire sections (3,5) are laterally spaced apart along an intermediate dorsal region (7) of the hand.