Patent No. 597432 Disclosed is a pharmaceutical composition comprising: 1) an isolated or synthetic dinucleotide analogue, its salt or ester, comprising one 5-aza-cytosine as a base residue in the sequence of the dinucleotide analogue, wherein the dinucleotide is linked with a phospholinker having only one phosphorus wherein the dinucleotide analogue has a general formula of: a. Z-L-G, or G-L-Z, wherein Z is 5-aza-cytosine； G is guanine； and L is a chemical linker covalently linking Z and G； or b. 5'-DpG-3' or 5'GpD-3', wherein D is decitabine； p is a phospholinker； and G is deoxyguanosine； and 2) a pharmaceutically-acceptable carrier, wherein the pharmaceutically-acceptable carrier comprises a combination of propylene glycol and glycerine.
