Methods and pharmaceutical compositions for regulations of Guanine- (G-) and/or Guanine-cytosine-rich (GC-rich) nucleic acid expressions are provided. The methods include a step of interacting the G- and/or GC-rich region of the nucleic acid with thalidomide, and the pharmaceutical compositions include the thalidomide and a pharmaceutical carrier.本案提出了調控富含鳥糞嘌呤(Guanine)及/或鳥糞嘌呤(Guanine)與胞嘧啶(Cytosine)的核酸之表現的方法及醫藥組合物。其中，所述方法包含以沙利竇邁(thalidomide)和所述鳥糞嘌呤(Guanine)及/或鳥糞嘌呤(Guanine)與胞嘧啶(Cytosine)作用的一步驟；而所述醫藥組合物包含沙利竇邁(thalidomide)和一醫藥載體。
