DEGOEY, DAVID A.,KATI, WARREN M.,HUTCHINS, CHARLES W.,DONNER, PAMELA L.,KRUEGER, ALLAN C.,RANDOLPH, JOHN T.,MOTTER, CHRISTOPHER E.,NELSON, LISSA T.,PATEL, SACHIN V.,MATULENKO, MARK A.,KEDDY, RYAN G.,J
申请号：
PE0019872013
公开号：
PE10832014A1
申请日:
2010.06.10
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a compusto of formula (i) or a pharmaceutically acceptable Salt thereof, where X is the (ii), and is optionally substituted with one or more ra where X3 is n, L1, L2, L3 are links, a and B are each, 1h benzimidazole, among others figure d (iii), Where RN is Hydrogen, Among others J is carbociclo C3 - C6, three to six members Heterocycles RC is H, halogen, hydroxylAmong others, RD is Halogen, Nitro, Oxo, fosfonoxi, among others R2 and R5, taken together with the Atoms to which they are United, form pyrrolidine R9 and R12, taken together with the Atoms to which they are attached, which are optionally substituted pyrrolidine.Favorites are composite ([(2S, 3R, 4R, 5S) - 1 - (4-fluorophenyl) - 3,4 - dimetoxipirrolidin - 2.5 - diyl] {bencen bis - (2S) - pyrrolidin-3-yl diilcarbamoil 4.1 - 2.1 - diyl [(2S) - 3,3-dimethyl-1 - oxobutan - 1.2 - diyl]} biscarbamato) dimethyl ([1 - (4-tert-butylphenyl) - 1H pyrrole - 2.5 - diyl] bis {bencen diilcarbamoil - 4.1 - 2.1 - (2S) - pyrrolidin-3-yl di Il [(2S) - 3 - methyl - 1 - oxobutan - 1,2 - dimethyl biscarbamato diyl]}), among others.It also relates to a Pharmaceutical composition. These compounds inhibit the replication of the hepatitis C virus (HCV)SE REFIERE A UN COMPUSTO DE FORMULA (I), O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE X ES LA FIGURA (II), Y ESTA OPCIONALMENTE SUSTITUIDO CON UNO O MAS RA DONDE X3 ES N, L1, L2, L3 SON ENLACES, A Y B SON CADA UNO, 1H-BENZIMIDAZOL, ENTRE OTROS D ES LA FIGURA (III), DONDE RN ES HIDROGENO, ENTRE OTROS J ES CARBOCICLO DE C3-C6, HETEROCICLO DE 3 A 6 MIEMBROS RC ES H, HALOGENO, HIDROXILO, ENTRE OTROS RD ES HALOGENO, , NITRO, OXO, FOSFONOXI, ENTRE OTRAS R2 Y R5 TOMADOS JUNTOS CON LOS ATOMOS A LOS CUALES ESTAN UNIDOS, FORMAN PIRROLIDINA R9 Y R12 TOMADOS JUNTOS CON LOS ATOMOS A LOS CUALES ESTAN UNIDOS, PIRROLIDINA QUE ESTAN OPCIONALMENTE SUSTITUIDO. SON COMPUESTO FAVORITOS ([(2S,3R,4R,5S)-1-(4-FLUOROFENIL)-3,4-DIMETOXIPIRROLIDIN-2,5-DIIL]BIS{BENCEN-4,1-DIILCARBAMOIL(2S)PIR
