FINLAY, Maurice Raymond Verschoyle,NISSINK, Johannes Wilhelmus Maria,RAUBO, Piotr Antoni,PERKINS, David Robert,SMITH, Peter Duncan,BAILEY, Andrew
申请号：
PE2018001012
公开号：
PE20181522A1
申请日:
2016.11.30
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to a formula (I) derivative substituted from 1,3,4-thiodiazoam,Q is piridazin-3-ilo, 6-fluoropiridazin-3-ilo, R1 is h, R2 and R3 are C1-C6, together - (CH2) 3,Among others, n is 0, 1 or 2； R4 is halogen, methyl, methoxy, etc. These compounds work on glucose-1 (gls1) and help prevent glucose-1-mediated diseases, including cancer. Three three three three three two three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three three, among others.Se refiere a un derivado de 1, 3, 4-tiadiazol sustituido de formula (I), en donde Q es piridazin-3-ilo, 6-fluoropiridazin -3-ilo； R1 es H； R2 y R3 son alquilo C1-C6, y tomados juntos son -(CH2)3-, entre otros； n es 0, 1 o 2； y R4 es halo, metilo, metoxi, entre otros. Dichos compuestos actuan sobre la enzima glutaminasa 1 (GLS1) y son utiles para prevenir la enfermedad mediada por GLS1, incluido el cancer. Entre los compuestos preferidos tenemos los siguientes: (2S)-2-(dimetilamino)-2-fenil-N-[5-[[(3R)-1-piridazin-3-il-pirrolidin-3-il]amino-1,3,4-tiadiazol-2-il]acetamida； (2S)-2-(dimetilamino)-2-(4-fluorofenil)-N-[5-[[(3R)-1-piridazin-3-il-pirrolidin-3-il]amino-1,3,4-tiadiazol-2-il]acetamida； entre otros.
