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Bicyclic tramadol derivatives to control pain
专利权人:
Eli Lilly and Company
发明人:
DEFAUW, Jean Marie,HOLMSTROM, Scott Dale,CHEN, Shuhui,ZHANG, Yang,WU, Wentao,PENG, Xian,MA, Yujuan,LU, Lun
申请号:
ES12701809
公开号:
ES2612495T3
申请日:
2012.01.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound or salt thereof, of formula I: ** Formula ** in which A is selected from: ** Formula ** or ** Formula ** R1 is hydrogen, C1-C5 alkyl, C1-C5 haloalkyl, alkanol C1-C5, - (C1-C5 alkyl) phenyl or phenyl, or a group of the formula -C (O) -R12, where R12 may be C1-C5 alkyl, C1-C5 alkoxy, C1-C5 haloalkyl, alkanol C1-C5, - (C1-C5 alkyl) phenyl or phenyl; R2 is hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen, C1-C5 haloalkyl or C1-C5 haloalkoxy; R3 is hydrogen, C1-C5 alkyl, C1-C5 alkoxy, halogen, C1-C5 haloalkyl or C1-C5 haloalkoxy; R4 is hydrogen, C1-C5 alkyl or - (C1-C5 alkyl) phenyl; R5 is hydrogen, C1-C5 alkyl or - (C1-C5 alkyl) phenyl; R11 is hydrogen or C1-C5 alkyl.Un compuesto o sal del mismo, de fórmula I: **Fórmula** en la que A se selecciona de: **Fórmula** o **Fórmula** R1 es hidrógeno, alquilo C1-C5, haloalquilo C1-C5, alcanol C1-C5, -(alquil C1-C5)fenilo o fenilo, o un grupo de fórmula -C(O)-R12, en la que R12 puede ser alquilo C1-C5, alcoxi C1-C5, haloalquilo C1-C5, alcanol C1-C5, -(alquil C1-C5)fenilo o fenilo; R2 es hidrógeno, alquilo C1-C5, alcoxi C1-C5, halógeno, haloalquilo C1-C5 o haloalcoxi C1-C5; R3 es hidrógeno, alquilo C1-C5, alcoxi C1-C5, halógeno, haloalquilo C1-C5 o haloalcoxi C1-C5; R4 es hidrógeno, alquilo C1-C5 o -(alquil C1-C5)fenilo; R5 es hidrógeno, alquilo C1-C5 o -(alquil C1-C5)fenilo; R11 es hidrógeno o alquilo C1-C5.
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