One-time programmable integrated circuit security is described. An example of a method of protecting memory assets in an integrated circuit includes sampling values of multiple OTP memory arrays and comparing the sampled value of each OTP memory array with the sampled value of each other OTP memory array and with an unprogrammed OTP memory array value. The method further includes determining if an integrated circuit performance fault has occurred based on the compared sampled values, booting the integrated circuit, and operating the integrated circuit with access to memory determined by the fault occurrence determination.
