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MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
专利权人:
SEATTLE GENETICS; INC.
发明人:
DORONINA, SVETLANA, O.,SENTER, PETER, D.,TOKI, BRIAN, E.,EBENS, ALLEN, J.,KLINE, TONI, BETH,POLAKIS, PAUL,SLIWKOWSKI, MARK, X.,SPENCER, SUSAN, D.
申请号:
SG2013067566
公开号:
SG195524A1
申请日:
2004.11.05
申请国别(地区):
SG
年份:
2013
代理人:
摘要:
296AbstractMONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDSAuristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugateswere active in vitro and in vivo. (Figure 1)
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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