MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS

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专利权人:

SEATTLE GENETICS; INC.

发明人:

DORONINA, SVETLANA, O.,SENTER, PETER, D.,TOKI, BRIAN, E.,EBENS, ALLEN, J.,KLINE, TONI, BETH,POLAKIS, PAUL,SLIWKOWSKI, MARK, X.,SPENCER, SUSAN, D.

申请号：

SG2013067566

公开号：

SG195524A1

申请日:

2004.11.05

申请国别(地区):

SG

年份:

2013

代理人:

摘要：

296AbstractMONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDSAuristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugateswere active in vitro and in vivo. (Figure 1)

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