A plasma toothbrush having an atmospheric plasma generator integrated with a toothbrush and the shape of a conventional toothbrush so that ordinary users operate the plasma toothbrush in a convenient and safe way for treating the teeth and oral cavity with plasma, for which the plasma toothbrush is equipped, in the lower end portion, with the plasma generator that employs dielectric barrier discharge, receives electric power using a domestic power source, rechargeable battery or disposable dry cell, includes an electrode plate to which high voltage is applied and a dielectric layer that covers the electrode plate and assumes the shape of a conventional toothbrush.