The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them.本發明係關於VEGF拮抗劑及新穎抗α5β1抗體用於治療癌症及抑制血管生成及/或血管滲透,包括抑制疾病中之異常血管生成之用途。本發明亦關於包含新穎抗α5β1抗體之組合物及套組,及製造及使用彼等之方法。