PROBLEM TO BE SOLVED: To provide a production method and production apparatus of platelet preparations that can recover from the liquid including megakaryocytes and platelets, concentrate, and wash only platelets efficiently, and to provide platelet preparations produced by this production method or this production apparatus.SOLUTION: The invention relates to a method comprising a separation step of making the culture medium that is a liquid containing megakaryocytes and platelets pass through a separation membrane 7 that is a separation member in a liquid, and capturing the megakaryocytes by the separation membrane 7 and separating the megakaryocytes from the platelets a concentration step of increasing the number of the platelets contained in a unit volume by making the culture medium containing the platelets separated in the separation step pass through a hollow fiber membrane 15a of an enrichment unit 13 in a liquid, capturing the platelets by the hollow fiber membrane 15a of the enrichment unit 13, and subsequently recovering the captured platelets with a recovery liquid that is a liquid for a recover and a feed adjusting step of adjusting the amount of the liquid to be fed in the concentration step, the liquid containing platelets.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】巨核球と血小板とが含まれる液体から効率的に血小板のみを回収、濃縮および洗浄できる血小板製剤の製造方法および製造装置、およびこの製造方法またはこの製造装置で製造された血小板製剤を提供することである。【解決手段】液体中にある分離部材である分離膜7に巨核球と血小板とが含まれる液体である培養液を通過させ、分離膜7により巨核球を捕捉して巨核球と血小板とを分離する分離工程と、液体中にある濃縮ユニット13の中空糸膜15aに分離工程で分離した血小板が含まれる培養液を通過させ、濃縮ユニット13の中空糸膜15aにより血小板を捕捉した後に回収用の液体である回収液で捕捉した血小板を回収することで単位体積中に含まれる血小板数を増加させる濃縮工程と、濃縮工程に供給する血小板が含まれる液体の量を調整する供給量調整工程と、からなる。【選択図】図1
