LI, PENG,WENNOGLE, LAWRENCE P.,ZHAO, JUN,ZENG, HAILIN
申请号：
PE0011692011
公开号：
PE09222011A1
申请日:
2009.12.07
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to Derivatives of 3 - (Uncle, sulfinyl or sulfonyl) - 7.8 - dihydro - (1H \/ 2h) imidazo [1,2-a] pyrazolo [4,3] pyrimidine - and - 2 (5H) - 3 - (onas or Uncle, sulfinyl or sulfonyl) - - - trihidro 7,8,9 (1h and 2H - pirimido) [1,2-a] pyrazolo [4,3] pyrimidine - and - 2 (5H) - one of formula (ii) where l is s, so or SO2 r1 is H or alkyl (c1-c4) R2 and R3 are each h, alkyl (C1 - C6)Among other Halo or optionally substituted with Hydroxy is H or alkyl R4 and R5 (C1 - C6) is heteroarilalquilo, - D - e - F, among others, where d is alquileno (c1-c4) and is a Link, alquinileno (c2-c4), heteroarileno arylene or f is H haloalquilo, aryl, (c1-c4), among others, R6 is H, alkyl (c1-c4), moped Oalquilo (C3 - C7), aryl, among others n is 0 OR 1 (c) (r13r14) - Where R13 and R14 are each h,Alkyl (c1-c4), aryl, heteroaryl, among others.Preferred compounds are: (6aR, 9aS) - 5,6a, 7,8,9,9a - hexahidro - 5 - methyl - 3 - (phenylthio) - 2 - (4 - (2 - 6 - fluoropiridin - il) benzyl) - ciclopent [4,5] imidazo [1,2-a] pyrazolo [4,3] pyrimidine - and - 4 (2H) - One (6aR, 9aS) - 5,6a, 7,8,9,9a - hexahidro - 5 - methyl - 3 - (fenilsulfinil) - 2 - (4 - (2 - 6 - fluoropiridin - il) benzyl) - ciclopent [4,5] imidazo [1 2 -] pyrazolo [4.3] pyrimidine - and 4 - (2H) - One among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of phosphodiesterase 1 (PDE1) being useful in the treatment of Parkinsons disease, Alzheimers disease, depression, bipolar disorderSE REFIERE A DERIVADOS DE 3-(TIO, SULFINIL O SULFONIL)-7,8-DIHIDRO-(1H O 2H)-IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(5H)-ONAS O 3-(TIO, SULFINIL O SULFONIL)-7,8,9-TRIHIDRO-(1H O 2H)-PIRIMIDO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(5H)-ONA DE FORMULA (II) DONDE L ES S, SO O SO2 R1 ES H O ALQUILO(C1-C4) R2 Y R3 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS OPCIONALMENTE SUSTITUIDO CON HALO O HIDROXI R4 ES H O ALQUILO(C1-C6) R5 ES HETEROARILALQUILO, -D-E-F, ENTRE OTROS, EN DONDE D ES ALQUILENO(C1-C4) E ES UN ENLA
