DERIVADOS (HETEROCICLO-TETRAHIDRO-PIRIDIN)-(PIPERAZINIL)-1-ALCANONA Y (HETEROCICLO-DIHIDRO-PIRROLIDIN)-(PIPERAZINIL)-1-ALCANONA COMO INHIBIDORES DE p75
Refers to a compound of formula (i), where n is 1 or 2 M is 0 OR 1 a represents a group of Heterocyclic Condensed formula (and) b is h W - is a nitrogenous heterocycle as (a), among others 1 - 2 represents 1 or 2 R2 is (b), among others or complete is a core of 6 ATOMS, aromatic or Saturated containing 1 or 2 n Atoms.Optionally substituted or complete is a core of 5 Atoms or saturated, aromatic, containing one atom of Oxygen, among other, optionally substituted X and X1 is CH or N R and R1 is H, halogen, among others R3 and R4 are H or c1-c6 alkyl group R5 and R6 are independently h, halogen Or alkoxy, (c1-c4), among others.Is the preferred Compound 1 - (benzo [b] tiofen - 7 - il - 3.6 - dihydro - 2H - pyridin-1-yl) - 2 - (3,5 Dimethyl 2,3,5,6 - tetrahydro - [] 1,2\u00b4 bipirazinil - 4-yl) - ethanone among others. Also referred to as a preparation method and a Pharmaceutical composition.These compounds inhibit the p75NTR receptor dimerization being useful for the treatment of schizophrenia, Epilepsy, depression, Heart Attack, pancreatitisSE REFIERE A UN COMPUESTO DE FORMULA (I): DONDE n ES 1 O 2 m ES 0 O 1 A REPRESENTA UN GRUPO HETEROCICLICO CONDENSADO DE FORMULA (Y) B ES H -W- ES UN HETEROCICLO NITROGENADO TAL COMO (a), ENTRE OTROS 1-2 REPRESENTA 1 O 2 R2 ES (b), ENTRE OTROS U COMPLETA ES UN NUCLEO DE 6 ATOMOS, AROMATICO O SATURADO QUE CONTIENE 1 O 2 ATOMOS DE N, OPCIONALMENTE SUSTITUIDO O U COMPLETA ES UN NUCLEO DE 5 ATOMOS, AROMATICO O SATURADO, QUE CONTIENE UN ATOMO DE N, DE OXIGENO, ENTRE OTROS OPCIONALMENTE SUSTITUIDO X Y X1 ES CH O N R Y R1 ES H, HALOGENO, ENTRE OTROS R3 Y R4 SON H O UN GRUPO ALQUILO C1-C6 R5 Y R6 SON INDEPENDIENTEMENTE H, HALOGENO, ALCOXI (C1-C4), ENTRE OTROS. ES COMPUESTO PREFERIDO: 1-(4-BENZO[b]TIOFEN-7-IL-3,6-DIHIDRO-2H-PIRIDIN-1-IL)-2-(3,5-DIMETIL-2,3,5,6-TETRAHIDRO-[1,2´]BIPIRAZINIL-4-IL)-ETANONA ENTRE OTROS. REFERIDO ADEMAS A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA DIMERIZACION DE
