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COMPOSITIONS AND METHODS FOR INHIBITING CELL ADHESION OR DIRECTION OF DIAGNOSTIC OR THERAPEUTIC AGENTS TO RGD LINKING SITES
专利权人:
ИНК. (US);АЛЛЕГРО ФАРМАСЬЮТИКАЛС
发明人:
МЭКЕЛ Майкл Джон (US),ПАРК Джон (US)
申请号:
RU2012118503/15
公开号:
RU2012118503A
申请日:
2010.11.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of inhibiting adhesion to RGD binding sites in a subject represented by a human or animal, wherein the method comprises the step of administering to the subject an effective amount of an RGCys-oic acid peptide or derivative thereof. The method of claim 1, wherein the RGCys-oic acid peptide or derivative thereof is radiolabeled and is used to detect a tumor. The method of claim 1, wherein the method provides at least one therapeutic or diagnostic effect selected from the group consisting of: inhibiting angiogenesis; treating or preventing angiogenesis-associated disease; inhibiting cell adhesion, migration and / or proliferation; treatment of inflammation; cancer treatment; treatment of metastasis; directing and releasing a therapeutic or diagnostic agent in the tumor; thrombosis treatment; provoking vitreolysis; provoking vitreoretinal detachment; facilitate vitreotomy; facilitating wound healing; radiolabeling of tissues expressing various integrins and the treatment of glaucoma. 4. The method according to claim 1, where the method provides the treatment of angiogenesis-associated disease or disorder selected from the group consisting of cancer, vascular defect, atherosclerosis, vascular adhesion, edema sclerosis, neovascularization of corneal transplant, neovascular glaucoma, diabetic retinopathy, pterygium, retinal degeneration dry and wet macular degeneration, neovascularization of the cornea, optic nerve ischemia, iris rubeosis, central vein occlusion, destruction of the epiretinal membranes, retrolental fibroplasia, ranulirovannogo conjunctivitis, rheumatoid arthritis, systemic edges1. Способ ингибирования адгезии к RGD сайтам связывания у субъекта, представленного человеком или животным, где способ включает стадию введения субъекту эффективного количества пептида RGCys-овой кислоты или его производного.2. Способ по п.1, где пептид RGCys-овой кислоты или его производное является радиомеченным и используется для детекции опухоли.3. Способ по п.1, гд
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