AL ALAWI FADIL,NANJAN KARTHIGEYAN,LEECH WAYNE FREDERICK
申请号：
NZ60403208
公开号：
NZ604032A
申请日:
2008.07.29
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a method of manufacturing a tablet formulated for administration to an animal containing at least one macrocyclic lactone (e.g. an avermectin such as abamectin or ivermectin) compound and at least one additional compound with anthelmintic activity by the steps of: (a) dissolving the macrocyclic lactone compound or compounds in at least one organic solvent (b) combining the mixture of step (a) with at least one organic co-solvent (c) combining the mixture of step (b) with: i. at least one additional compound with anthelmintic activity ii. at least one binder compound iii. at least one filler / bulking agent compound and, (d) drying the mixture of step (c) and (e) then mixing the dried mixture of step (d) with at least one further compound with properties selected from: a disintegrant, a glidant/free flowing agent a lubricant and combinations thereof.
