GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
申请号：
ARP180100956
公开号：
AR111474A1
申请日:
2018.04.16
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
This application is directed at compounds and salts as enzyme activity inhibitors, especially the activity of PI3-CINASA. Claim 1: A formula compound (1),R1 is heterosexual and consists of 5 or 6 members, including 1 to 3 heteroatoms independently selected from oxygen and nitrogen, and 1 to 2 substitutes independently selected from halogen, cyanide and alcoxi C83318322 6.- Apartments NHSO832222-C83218331 and 832626；- Xr3 and C83218331832626 asphalt, of which C8321838326 asphalt was replaced； R2 ES-Or8308；- Conhr83090 or 5 or 6 members with one to three irregular atoms independently selected from oxygen and nitrogen are replaced by one to two alternatives independently selected from halogen, cyanide and alcoxi C8331832626.- Apartments NHSO832222-C83218331 and 832626；- Conr8310；R8311；- C831221 and C832131 and 83266 leases, of which C8321838326832663 is replaced by one or two alternatives independently selected from Hidroxi to NR8313； R830404；R3_is an isopropyl compound with 5-6 members. Its isopropyl compound contains one or two heteroatoms independently selected from oxygen and nitrogen, which can be replaced by one or three substitutes independently selected from C8321833146 tar.E.C8308C8321C8331832625 or C833183316C5 or 6 substitutes containing one or two abiotic atoms selected from oxygen and nitrogen C83208C83326CHC-C832183832625 and H； TEROCILO can be replaced by one or three alternatives independently selected from halogen-CO-tar C8331832626.- CO832222-C832131 and C83218331833262 can be replaced by-Or1.E.C83099a is hydrogen or C8321318332618326 selectively replaced by six member isomers. In the isomers, oxygen or nitrogen atoms can be replaced by C8321I8331832626 tar.R8310 and R8311；A. With the attached nitrogen atoms, a 5-6 member isomeric compound can be formed. In the isomeric compound, an oxygen atom or an additional nitrogen atom can be optionally contained and alternatively replaced by C832183331 tar.R831222 is a 5-9-member heterocyclic propylene, which c
