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СПОСОБЫ ЛЕЧЕНИЯ ДИСФУНКЦИИ МЕЙБОМИЕВЫХ ЖЕЛЕЗ
专利权人:
ДжиТиЭкс; ИНК. (US)
发明人:
ДАЛТОН Джеймс Т. (US),ЭСВАРАКА Джитендра (US)
申请号:
RU2012134351/15
公开号:
RU2012134351A
申请日:
2011.01.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating meibomian gland dysfunction, improving lipid composition of lacrimal fluid secretion or treatment of abnormal meibomian glands, comprising administering to a subject in need thereof, a compound of formula I: wherein X represents O or S G is O or S Z represents NOili CN Y is halogen or CF Q represents a halogen atom, NHCOR or CN T represents OH, oR or NHCOR R is alkyl, aryl, alkenyl, halogen or OH R is CH, CF, CHF, CHF, CHCHili CFCF and n is 0 or 1, or its isomer, pharmaceutically acceptable salt, pharmaceutical product, N-oxide, hydrate or any kombinatsii.2. A method according to claim 1, wherein said compound is selected from the following structures: 3. A method according to claim 1, wherein said method further normalizes zhelez.4 meibomian secretion. A method according to any one of claims 1-3, wherein the lipid content in improved tear zhidkosti.5. A method according to any one of claims 1-3, wherein the fatty acid content is increased in the tear zhidkosti.6. A method according to any one of claims 1-3, wherein increased ratio of palmitate stearate in lacrimal zhidkosti.7. A method according to any one of claims 1-3, wherein the number of clogged reduced meibomian zhelez.8. A method according to any one of claims 1-3, wherein the time gap uvelicheno.9 tear film. A method according to any one of claims 1-3, wherein the viscosity of the secretions of the meibomian glands snizhena.10. A method according to any one of claims 1-3, wherein the transparency secretion povyshena.11 meibomian glands. A method according to any one of claims 1-3, wherein the time period between the secretions of the meibomian glands umenshen.12. A method according to claim 1, wherein said dysfunction is the edge of the eyelid redness at subekta.13. The method of claim 12, where the reduction of redness measured photometrically or visa1. Способ лечения дисфункции мейбомиевых желез, улучшения липидного состава слезной жидкости или лечения аномальной секреции мейбомиев
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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