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APPLICATION OF CATHEPSIN K INHIBITION FOR TREATMENT AND / OR PREVENTION OF PULMONARY HYPERTENSION AND / OR HEART FAILURE
专利权人:
БАЙЕР ИНТЕЛЛЕКТУЭЛЬ ПРОПЕРТИ ГМБХ (DE)
发明人:
ГОЛЬЦ Штефан (DE),ДЕЛЬБЕК Мартина (DE),МАЙЕР Хайнрих (DE),ГЕЕРТС Андреас (DE),МОНДРИТЦКИ Томас (DE),ТРЮБЕЛЬ Хуберт (DE)
申请号:
RU2013155509/15
公开号:
RU2013155509A
申请日:
2012.05.11
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Cathepsin K inhibitor for use in a method for the treatment and / or prevention of pulmonary hypertension and / or acute or chronic heart failure. The compound according to the formulas (I) to (XV) MIV 701 (X), Ono 5334 (XI), RO 4383315 (XII), SAR-114137 (XIII), MIV 710 (XIV) or MIV 711 (XV), for use in a method of treating and / or preventing pulmonary hypertension and / or acute or chronic heart failure and / or a combination thereof. 3. A compound of formula (I) for use in a method for treating and / or preventing pulmonary hypertension and / or acute or chronic heart failure and / or a combination thereof. 4. A compound of formula (I) or its salts, solvates and solvates of salts, for use in a method for the treatment and / or prevention of pulmonary hypertension. 5. An inhibitor according to claim 1 or a compound according to one of claims. 2-4, wherein the inhibitor or compound is intended for oral administration. 6. A method for the treatment and / or prevention of pulmonary hypertension and / or acute or chronic heart failure in humans and animals by administering a therapeutically effective amount of at least one inhibitor according to claim 1 or one compound according to one of claims. 2-4, characterized in that the drug contains at least one inhibitor according to claim 1 or one compound according to one of claims. 2-4 in combination with an inert, non-toxic, pharmaceutically acceptable additional component, or the drug contains at least one inhibitor according to claim 1 or one compound according to one of claims. 2-4 in combination with an inert, non-toxic, pharmaceutically acceptable additional component and at least one other pharmaceutically active compound.1. Ингибитор катепсина K для применения в способе лечения и/или профилактики легочной гипертензии и/или острой или хронической сердечной недостаточности.2. Соединение в соответствии с формулами от (I) до (XV)MIV 701 (X), Ono 5334 (XI), RO 4383315 (XII), SAR-114137 (XIII), MIV 710 (XIV) или MIV 7
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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