КАО Юй-Сюнь,ЛИОУ Цзин-Пин,ХУН Ко-Шэн,ЧЭНЬ И-Джэнь,ШАНЬ Пэй-Вэнь
申请号：
RU2014114860
公开号：
RU2014114860A
申请日:
2012.09.15
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compounds of formula (I) for the treatment of heart failure or nerve cell damage where B represents R, C (O) R, CHR, SOR, SOR or SONRR ′, C represents R, C (O) R, CHR, SOR or CH = CHC (O) NHOH, each of the groups X, X, Xi X independently represents H, halogen, nitro group, nitroso group, OR or CH = CHC (O) NHOH, and each of the groups R and R ′ independently of one another is H, alkyl, alkenyl, alkynyl, aryl or heteroaryl. 2. Compounds according to claim 1, in which each of the groups C, X, Xi, X independently represents H, B represents SOR, and X represents CH = CHC (O) NHOH. 3. The compounds of claim 1, wherein the heart failure is caused by cardiac fibrosis, high blood pressure, myocardial infarction, myocardial ischemia, dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, cardiomyopathy takotsubo, diabetic cardiomyopathy. The compounds of claim 3, wherein the heart failure is caused by cardiac fibrosis or high blood pressure. The compounds of claim 1, wherein the nerve cell damage is a traumatic brain injury or ischemic stroke. A method for treating a patient suffering from heart failure or damage to nerve cells, comprising administering to the patient an effective amount of a compound according to claim 1.7. The method according to claim 6, wherein each of the groups C, X, Xi X is independently H, B is SOR, and X is CH = CHC (O) NHOH. 8. The method of claim 6, wherein the patient is a human. The method of claim 6, wherein the heart failure is heart failure caused by cardiac fibrosis,1. Соединения формулы (I) для лечения сердечной недостаточности или поражения нервных клетокгде В представляет собой R, C(O)R, CHR, SOR, SOR или SONRR′, С представляет собой R, C(O)R, CHR, SOR или CH=CHC(O)NHOH, каждая из групп Х, X, Хи Xнезависимо друг от друга представляет собой H, галоген, нитро-группу, нитрозо-группу, OR или CH=CHC(O)NHOH, а каждая из групп R и R′ независимо друг от друга представляет собой Н, алкил, алкенил, алкинил, арил или
