PROBLEM TO BE SOLVED: To provide an inhibitor for enhanced vascular permeability which inhibits the breakdown of blood-brain barrier, and is useful to prevent or treat the pathology and disease caused by enhanced vascular permeability such as cerebral edema, cerebral hemorrhage, and cerebrovascular disorder.SOLUTION: The inhibitor for enhanced vascular permeability contains an IP receptor agonist or a prostacyclin production promoting agent, and has an action for inhibiting cell death in pericyte.COPYRIGHT: (C)2015,JPO&INPIT【課題】血液脳関門の破綻を抑制し、脳浮腫、脳内出血、脳血管障害等の血管透過性亢進に起因する病態および疾患予防または治療に有効な血管透過性亢進抑制剤を提供すること。【解決手段】IP受容体アゴニストまたはプロスタサイクリン産生促進物質を含有し、ペリサイトの細胞死を阻害する作用を有する血管透過性亢進抑制剤。【選択図】なし
