Teresa Sanchez;Kevin Patrick Claffey;Timothy Hla;Ji-Hye Paik
发明人:
Timothy Hla,Teresa Sanchez,Kevin Patrick Claffey,Ji-Hye Paik
申请号：
US12894783
公开号：
US09101575B2
申请日:
2010.09.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Agonists of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels.
