HLA, TIMOTHY,SANCHEZ, TERESA,PAIK, JI-HYE,CLAFFEY, KEVIN P.
申请号：
CA2529318
公开号：
CA2529318C
申请日:
2004.06.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated froms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels.
