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Double-stranded and single-stranded RNA molecules with 5′ triphosphates and their use for inducing interferon
专利权人:
发明人:
John J. Rossi,Dongho Kim,Patric Lundberg,Edouard Cantin
申请号:
US15255942
公开号:
US09938529B2
申请日:
2016.09.02
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects, such as anti-cancer effects. Also provided are methods for reducing or inhibiting interferon induction exhibited by such molecules, particularly siRNA and shRNA molecules produced in vitro.
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