Asymmetric interfering RNA compositions and uses thereof

• 收藏
• 分享

专利权人:

１グローブ;インスティテュート;1グローブ ヘルス インスティテュート エルエルシー;ヘルス;エルエルシー

发明人:

リー チャン チア,サン シャンガオ,ハリー ロゴフ,リー ユーチー

申请号：

JP2016113256

公开号：

JP6236498B2

申请日:

2016.06.07

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention provides double-stranded RNA molecules that are asymmetrical in strand length. The RNA molecule of the invention, the asymmetric RNA duplex, has one or two overhangs at the end. In one aspect, these novel RNA duplex molecules serve as effective mimetics of miRNA. In another aspect, they are designed to function as effective inhibitors of miRNA. Accordingly, the RNA molecules of the present invention can be used to modulate miRNA pathway activities, with tremendous implications for research, drug discovery and development, and treatment of human diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/