Thomas D. Wang,Katsuo Kurabayashi,Kenn Oldham,Zhen Qiu
申请号：
US12916159
公开号：
US09921406B2
申请日:
2010.10.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
An optical device is described that may be used as a microscope system for real-time, three-dimensional optical imaging. The device includes a miniature, fiber optic, intra-vital probe microscope that uses a dual-axes confocal architecture to allow for vertical scanning perpendicular to a surface of the sample (e.g., a tissue surface). The optical device can use off-axis illumination and collection of light to achieve sub-cellular resolution with deep tissue penetration. The optical device may be used as part of an integrated molecular imaging strategy using fluorescence-labeled peptides to detect cell surface targets that are up-regulated by the epithelium and/or endothelium of colon and breast tumors in small animal models of cancer.
