Oligonucleotide-cyclopropapyrroloindole conjugates as sequence specific hybridization and crosslinking agents for nucleic acids

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专利权人:

EPOCH PHARMACEUTICALS, INC.

发明人:

KUTYAVIN, IGOR V.,LUKHTANOV, EUGENY A.,GAMPER, HOWARD B.,MEYER, JR., RICH B.,GALL, ALEXANDER

申请号：

US19960583435

公开号：

US5659022(A)

申请日:

1996.01.05

申请国别(地区):

美国

年份:

1997

代理人:

摘要：

Covalently linked conjugates of oligonucleotides (ODNs) with a cyclopropapyrroloindole moiety or an analog thereof, selectively and efficiently alkylate and crosslink with nucleic acid sequences that are complementary to the base sequence of the ODN.

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