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Immunosuppression-Reverting Oligonucleotides Inhibiting the Expression of IDO
专利权人:
Secarna Pharmaceuticals GmbH &; Co. KG
发明人:
Richard KLAR,Frank JASCHINSKI
申请号:
US16340292
公开号:
US20200163988A1
申请日:
2017.10.09
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention refers to immunosuppression-reverting oligonucleotides comprising 12 to 18 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with a nucleic acid sequence of indoleamine-2,3-dioxygenase (IDO-1) of SEQ ID NO.1 (human) in a hybridizing active area, wherein the oligonucleotide inhibits at least 50% of the IDO-1 expression. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide.
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