It includes the oligonucleotides of 12 to 18 nucleotide that the present invention, which refers to that immunosupress is replied, whereinAt least one nucleotide is modified, and with SEQ ID NO in the sequence table of the ectoenzyme (CD73) of the nucleic acid sequence of oligonucleotide hybridization. SEQ ID NO in 1 (people) and/or a sequence table. 2 (mouse), wherein the oligonucleotides inhibits the expression of at least 50% CD73. The invention further relates to a kind of pharmaceutical compositions, and it includes this oligonucleotides.
