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OLIGONUCLEOTIDES D'INVERSION DE L'IMMUNOSUPPRESSION INHIBANT L'EXPRESSION DE L'IDO
专利权人:
SECARNA PHARMACEUTICALS GMBH & CO. KG
发明人:
KLAR, RICHARD,JASCHINSKI, FRANK
申请号:
CA3039071
公开号:
CA3039071A1
申请日:
2017.10.09
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention refers to immunosuppression-reverting oligonucleotides comprising 12 to 18 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with a nucleic acid sequence of indoleamine-2,3- dioxygenase (IDO-1) of SEQ ID NO.l (human) in a hybridizing active area, wherein the oligonucleotide inhibits at least 50 % of the IDO-1 expression. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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