OLIGONUCLEOTIDES D'INVERSION DE L'IMMUNOSUPPRESSION INHIBANT L'EXPRESSION DE L'IDO

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专利权人:

SECARNA PHARMACEUTICALS GMBH & CO. KG

发明人:

KLAR, RICHARD,JASCHINSKI, FRANK

申请号：

CA3039071

公开号：

CA3039071A1

申请日:

2017.10.09

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention refers to immunosuppression-reverting oligonucleotides comprising 12 to 18 nucleotides, wherein at least one of the nucleotides is modified, and the oligonucleotide hybridizes with a nucleic acid sequence of indoleamine-2,3- dioxygenase (IDO-1) of SEQ ID NO.l (human) in a hybridizing active area, wherein the oligonucleotide inhibits at least 50 % of the IDO-1 expression. The invention is further directed to a pharmaceutical composition comprising such oligonucleotide.

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