LEE, Bong-Yong,이봉용,HWANG, Yong Youn,황용연,YUN, Sun Kyu,윤선규,SAH, Hong Kee,사홍기,KIM, Hong-Kee,김홍기,LEE, Kyu Ho,이규호,HONG, Seok Hyun,홍석현,LEE, Yoon-Jung,이윤정,OH, Joon-Gyo,오준교,UM, Key- An,엄기안
申请号：
KRKR2011/008469
公开号：
WO2012/064087A2
申请日:
2011.11.08
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a pharmaceutical composition including a polymer microsphere that contains anastrozole as an active ingredient, and more particularly, to a pharmaceutical composition for cancer treatment or prevention including a polymer microsphere that contains anastrozole, which is prepared by a method comprising the following steps: preparing a dispersion by mixing a polymer compound, anastrozole, and a water insoluble organic solvent preparing an emulsion by mixing the dispersion with a dispersion solvent eliminating the water insoluble organic solvent from the emulsion by adding a base or an acid and obtaining the polymer microsphere from which the water insoluble organic solvent is removed and re-dispersing same in the heated dispersion solvent. The present invention also relates to a method for treating or preventing the cancer and usage thereof. The composition of the present invention does not involve the existing steps of solvent evaporation or solvent extraction, uses little amount of water thereby minimizing waste water generation, and allows low density of solvent remnants inside the polymer microsphere. Also, the present invention is effective for manufacturing sustained-release medicine including anastrozole, as the speed of releasing anastrozole in the body can be adjusted.La présente invention porte sur une composition pharmaceutique comprenant des microsphères de polymère qui contiennent de lanastrozole en tant que principe actif et, plus particulièrement, sur une composition pharmaceutique pour le traitement ou la prévention du cancer comprenant des microsphères de polymère qui contiennent de lanastrozole, qui est préparée par un procédé comprenant les étapes suivantes : la préparation dune dispersion par mélange dun composé polymère, danastrozole et dun solvant organique insoluble dans leau la préparation dune émulsion par mélange de la dispersion avec un solvant de dispersion lélimination du solvant organique insoluble dans l
