加利福尼亞大學董事會;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
AKASSOGLOU, Katerina,凱特琳娜.阿卡索格魯
申请号：
HK12109512.6
公开号：
HK1168871B
申请日:
2012.09.27
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention provides an isolated antibody that binds a fibrin or fibrinogen &gamma；C domain. In various aspects, the antibody inhibits microglial adhesion to the fibrin or fibrinogen &gamma；C domain, inhibits Mac-1 binding to the fibrin or fibrinogen &gamma；C domain, and/or suppresses clinical symptoms of Experimental Autoimmune Encephalomyelitis (EAE). Various methods of using the antibodies, pharmaceutical compositions, kits, vectors, cells comprising the vectors, and antibody generating methods are provided.
