The present invention provides an isolated antibody that binds a fibrin or fibrinogen &gamma；C domain. In various aspects, the antibody inhibits microglial adhesion to the fibrin or fibrinogen &gamma；C domain, inhibits Mac-1 binding to the fibrin or fibrinogen &gamma；C domain, and/or suppresses clinical symptoms of Experimental Autoimmune Encephalomyelitis (EAE). Various methods of using the antibodies, pharmaceutical compositions, kits, vectors, cells comprising the vectors, and antibody generating methods are provided.
