Disclosed are an RNAi sequence, an inhibitor, and an inhibition method that specifically inhibits expression of 78-kDA glucose-regulated protein, in which a segment of RNA interference sequence: 5'-AAGGATGGTTAATGATGCTGAGAA-3', that induces complementation with 78-kDA glucose-regulated protein is designed. The sequence forms a special hair-pin structure inside a cancer cell to realize specific and effective inhibition of the function of expression of 78-kDA glucose-regulated protein thereby inhibiting oncogenesis of cancer cell, including cell growth and invasive migration.一種專一性抑制葡萄糖調節蛋白-78表現之RNA干擾序列、抑制藥劑及抑制方法，係藉由設計一段可與葡萄糖調節蛋白-78分子產生互補作用的RNA干擾序列：5’-AAGGATGGTTAATGATGCTGAGAA-3’(SEQ ID NO：1)，此序列會在癌細胞內形成特殊的髮夾結構，達到專一性並有效地抑制葡萄糖調節蛋白-78表現的功能，進而抑制癌細胞之癌化過程，包含細胞生長和侵犯轉移。
