The present invention provides an interference ribonucleic acid for inhibiting matrix metalloproteinases 1 (MMP1). The interference ribonucleic acid contains 19 to 25 nucleotides, and is selected from the group that is made up of essentially identical sequences in SEQ ID NO.5 and/or SEQ ID NO.6, or essentially identical sequences in SEQ ID NO.7 and/or SEQ ID NO.8, or essentially identical sequences in SEQ ID NO.9, and SEQ ID NO.10, or essentially identical sequences of the above combination. By the specific combination of the interference ribonucleic acid with endogenous MMP1, the present invention can achieve the effect of inhibiting matrix metalloproteinases 1, and can be applied to be as a pharmaceutical composition to prevent or treat cancer metastasis or to improve wrinkle resistance of the skin.本發明提供一種用於抑制間質金屬蛋白酶1(MMP1)之干擾性核糖核酸,該干擾性核糖核酸具有19個至25個核苷酸,且該干擾性核糖核酸係選自由SEQ ID NO.5及SEQ ID NO.6、SEQ ID NO.7及SEQ ID NO.8、SEQ ID NO.9及SEQ ID NO.10所示之實質上相同之序列以及其組合所組成之群組;本發明藉由干擾性核糖核酸與內生性間質金屬蛋白酶1專一性結合,以達到抑制間質金屬蛋白酶1之效果,並可應用於製作預防或治療癌細胞之轉移或皮膚抗皺之醫藥組成物。
