PROBLEM TO BE SOLVED: To provide an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein.SOLUTION: In the polypeptide or peptidomimetic or fatty acid derivatives of them, the portion comprises an amino acid sequence of any of intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment. The functional fragment comprises at least 7 contiguous amino acids of the intracellular loops. The functional fragment or functional variant inhibits proliferation of a diseased cell. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Also provided are inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway.【課題】スムースンド（SMO）タンパク質の一部分のアミノ酸配列を含む、単離または精製された、ポリペプチド、またはペプチド模倣体の提供。【解決手段】該部分はSMOタンパク質のいずれかの細胞内ループのアミノ酸配列、その機能的断片、又は該部分か該機能的断片かのいずれかの機能的変異体を含み、該機能的断片は、該細胞内ループの少なくとも7つの連続するアミノ酸を含み、かつ該機能的断片または機能的変異体は病気の細胞の増殖を阻害する、ポリペプチド、もしくはペプチド模倣体、またはこれらの脂肪酸誘導体。関連する結合体、核酸、組み換え発現ベクター、宿主細胞、及び医薬組成物。病気細胞の増殖の阻害、癌の治療若しくは予防、新生物若しくは乾癬治療、ヘッジホッグシグナル伝達経路に係わる遺伝子の発現を阻害する。【選択図】図１
