The present invention provides compounds of Formula (I):,or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.本發明提供式(I)化合物：，或其立體異構體、互變異構體或醫藥學上可接受之鹽或溶劑合物，其中所有變數係如本文中所定義。此等化合物調節法尼醇X受體(farnesoid X receptor；FXR)之活性，例如作為促效劑。本發明亦係關於包含此等化合物之醫藥組合物及使用該等化合物及醫藥組合物治療與FXR失調相關之疾病、病症或病狀之方法，與FXR失調相關之疾病、病症或病狀為諸如病理性纖維化、移植排斥、癌症、骨質疏鬆及發炎性病症。
