The present invention provides compounds of Formula (I):,or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.本發明提供式(I)化合物：，或其立體異構體、互變異構體或醫藥學上可接受之鹽或溶劑合物，其中所有變數係如本文中所定義。此等化合物調節法尼醇X受體(FXR)之活性，例如作為促效劑。本發明亦關於包含此等化合物之醫藥組合物，及使用該等化合物及醫藥組合物治療與FXR調節異常相關之疾病、病症或病狀，諸如病理性纖維化、移植排斥、癌症、骨質疏鬆及發炎病症之方法。
