The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αV-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.本發明提供式(I)化合物：或其立體異構體、互變異構體或醫藥學上可接受之鹽或溶劑合物，其中所有變數如本文所定義。此等化合物為含αV之整合素之拮抗劑。本發明亦係關於包含此等化合物之醫藥組合物及藉由使用該等化合物及該等醫藥組合物治療與含αv之整合素失調相關聯之疾病、病症或病狀的方法，該疾病、病症或病狀諸如病理性纖維化、移植排斥、癌症、骨質疏鬆及發炎性病症。
