The present invention relates to polypeptides binding Aggrecan as well as ADAMTS5 and/or MMP13, more in particular to polypeptides that comprise or essentially consist of immunoglobulins binding Aggrecan as well as immunoglobulins binding ADAMTS5 and/or immunoglobulins binding MMP13 (also referred to herein as "polypeptides of the invention”, and“immunoglobulin(s) of the invention”, respectively). The invention also relates to constructs comprising such immunoglobulins, such as immunoglobulin single variable domains (ISVDs) or polypeptides as well as nucleic acids encoding such immunoglobulins or polypeptides (also referred to herein as “nucleic acid(s) of the invention”； to methods for preparing such immunoglobulins, polypeptides and constructs； to host cells expressing or capable of expressing such immunoglobulins or polypeptides； to compositions, and in particular to pharmaceutical compositions, that comprise such immunoglobulins, polypeptides, constructs, nucleic acids and/or host cells； and to uses of immunoglobulins, polypeptides, constructs, nucleic acids, host cells and/or compositions, in particular for prophylactic and/or therapeutic purposes, such as the prophylactic and/or therapeutic purposes mentioned herein. Other aspects, embodiments, advantages and applications of the invention will become clear from the further description herein.本發明是關於結合聚集蛋白聚醣以及ADAMTS5和/或MMP13的多肽，更特別地，是關於包括或基本上由結合聚集蛋白聚醣的免疫球蛋白以及結合ADAMTS5的免疫球蛋白和/或結合MMP13的免疫球蛋白所組成的多肽(在本文亦分別稱為「本發明的多肽」以及「本發明的免疫球蛋白」)。本發明亦是關於構築體，其包括此等免疫球蛋白(例如免疫球蛋白單可變結構域(ISVD)或多肽)以及編碼此等免疫球蛋白或多肽的核酸(在本文亦稱為「本發明的核酸」)；關於製備此等免疫球蛋白、多肽與構築體的方法；關於表現或可表現此等免疫球蛋白或多肽的宿主細胞；關於組成物，以及更特別地關於醫藥組成物，其包括此等免疫球蛋白、多肽、構築體、核酸和/或宿主細胞；以及關於免疫球蛋白、多肽、構築體、核酸、宿主細胞和/或組成物的用途，特別是用於預防和/或治療目的，例如本文所提及之預防和/或治療目的。從本文的進一步描述，本發明的其他態樣、具體實施例、優點和應用將變得清楚。
