A peritoneal dialysis patient assist device includes (i) a port holder shaped to hold a first connector and a first plug, (ii) a transfer set holder shaped to hold a second connector and a second plug, the transfer set holder rotatable and translatable with respect to the port holder, and (iii) an ultraviolet (“UV”) applicator positioned to radiate UV light on at least part of the first and second connectors when loaded into the port and transfer set holders, respectively.