A peritoneal dialysis patient assist device includes (i) a port holder shaped to hold a first connector and a first plug, (ii) a transfer set holder shaped to hold a second connector and a second plug, the transfer set holder rotatable and translatable with respect to the port holder, and (iii) an ultraviolet (&ldquoUV&rdquo) applicator positioned to radiate UV light on at least part of the first and second connectors when loaded into the port and transfer set holders, respectively.