Cyclopentyl (2S,4E)-2-amino-5-{3-[4-carbamoyl-5 (carbamoylamino)-2-thienyl]phenyl}pent-4-enoate Cyclopentyl 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-norvalinate Cyclopentyl (2S,4E)-2-amino-5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]-5-methylphenyl}pent-4-enoate Cyclopentyl (2S,4E)-2-amino-5-{5-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]-2-methylphenyl}pent-4-enoate Cyclopentyl O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]phenyl}-L-homoserinate Cyclopentyl O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienylJphenyl}-L-homoserinate Cyclopentyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}-L-alaninate and tert-Butyl N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thienyl]benzyl}-L-alaninate are hydrolysed to the corresponding carboxylic acids by intracellular carboxylesterases, and are useful for the inhibition of IKKβ activity.Le (2S,4E)-2-amino-5-{3-[4-carbamoyl-5(carbamoylamino)-2-thiényl]phényl}pent-4-énoate de cyclopentyle le 5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thiényl]phényl}-L-norvalinate de cyclopentyle le (2S,4E)-2-amino-5-{3-[4-carbamoyl-5-(carbamoylamino)-2-thiényl]-5-méthylphényl}pent-4-énoate de cyclopentyle le (2S,4E)-2-amino-5-{5-[4-carbamoyl-5-(carbamoylamino)-2-thiényl]-2-méthylphényl}pent-4-énoate de cyclopentyle le O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thiényl]phényl}-L-homosérinate de cyclopentyle le O-{3-[4-carbamoyl-5-(carbamoylamino)-2-thiénylphényl}-L-homosérinate de cyclopentyle le N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thiényl]benzyl}-L-alaninate de cyclopentyle et le N-{3-[4-carbamoyl-5-(carbamoylamino)-2-thiényl]benzyl}-L-alaninate de tert-butyle sont hydrolysés en les acides carboxyliques correspondants par des carboxylestérases intracellulaires et sont utiles pour linhibition de lactivité dIKK-β.
