INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT ill 1111u°11111DIVIIl °nolo How mil ammo oimIE (10) International Publication Number WO 2018/178304 Al (51) International Patent Classification: C07D 413/04 (2006.01) C07D 307/56 (2006.01) C07D 413/14 (2006.01) C07D 307/66 (2006.01) C07D 413/06 (2006.01) CO7D 307/68 (2006.01) C07D 417/04 (2006.01) COIF 9/6558 (2006.01) C07D 405/04 (2006.01) A61P 3/00 (2006.01) CO7D 271/10 (2006.01) A61P 9/00 (2006.01) CO7D 271/113 (2006.01) A61K 31/4245 (2006.01) CO7D 307/52 (2006.01) A61K 31/433 (2006.01) (21) International Application Number: PCT/EP2018/058225 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,960 31 March 2017 (31.03.2017) US (71) Applicant: PERENNA PHARMACEUTICALS, INC. [US/US]； 14785 Omicron Drive, Suite 100, San Antonio, Texas 78245 (US). (72) Inventors: SHI, Yuguang； 13915 Evelina, San Anto- nio, Texas 78253 (US). CHE, Daqing； 99 Waisha Road, Jianjiang, Taizhou, Zhejiang, 318000 (CN). BAELL, Jonathan； C/O Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052 (AU). LIU, Xiaoyu； East Lake High-Tech Development Zone of Wuhan, Biolake B3-4, No 666 Gaox- in Road, Wuhan, 430074 (CN). FU, Jiasheng； 221 Pelican CT, Foster City, California 94404 (US). (74) Agent: WATSON, Robert et al.； Mewburn Ellis LLP, City Tower, 40 Basinghall Street, London Greater London EC2V 5DE (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR,
