INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIP0 I PCT omit IIl °nolo onm iflo oimIE (10) International Publication Number WO 2018/151985 Al (51) International Patent Classification: A61K 31/506 (2006.01) A61P 1/16 (2006.01) CO7D 239/47 (2006.01) (21) International Application Number: PCT/US2018/017152 (22) International Filing Date: 07 February 2018 (07.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/CN2017/000157 14 February 2017 (14.02.2017) CN PCT/CN2017/117791 21 December 2017 (21.12.2017) CN (71) Applicant: ELI LILLY AND COMPANY [US/US]； Lilly Corporate Center, Indianapolis, Indiana 46285 (US). (71) Applicant (for MG only): LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD [CN/CN]； 780 Cailun Road, Rm. 819, Zhangjiang High Technology Park, Pudong New Area, Shanghai 20000 (CN). (72) Inventors: FAN, Mengyang； c/o Eli Lilly And Compa- ny, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). QIN, Luoheng； c/o Eli Lilly And Company, P.O. Box 6288, Indianaoplis, Indiana 46206-6288 (US). WEI, Yi； c/ o Eli Lilly And Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). ZHOU, Guoqiang； c/o Eli Lil- ly And Company, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). ZHOU, Jingye； c/o Eli Lilly And Com- pany, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). (74) Agent: MYERS, James B. et al.； ELI LILLY AND COM- PANY, P.O. Box 6288, Indianapolis, Indiana 46206-6288 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG
