PROCEDE DE PREPARATION DE PRECURSEUR D'IBRUTINIB

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专利权人:

LATVIAN INSTITUTE OF ORGANIC SYNTHESIS

发明人:

LEBEDEVS, ANTONS,PONOMARJOVS, JURIJS,VARACEVA, LARISA,CERNAKS, DMITRIJS,CERNOBROVIJS, ALEKSANDRS

申请号：

CA2987708

公开号：

CA2987708A1

申请日:

2015.11.13

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

A method for the preparation of ibrutinib's precursor, 3-(4-phenoxyphenyl)-1-((3R)-piperidin-3-il)-1H-pyrazolof [3,4-d]pyrimidin-4-amine, involving arylation of N-protected 1-(piperidin-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine in the presence of palladium catalyst, nitrogen-containing ligand, and base, with subsequent removal of the protecting groups by known methods, is reported. (Formula (II))

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/