A method for preparation of ibrutinib precursor

• 收藏
• 分享

专利权人:

Latvian Institute of Organic Synthesis

发明人:

Antons Lebedevs,Jurijs Ponomarjovs,Larisa Varaceva,Dmitrijs Cernaks,Aleksandrs Cernobrovijs

申请号：

GB201800657

公开号：

GB2556535A

申请日:

2015.11.13

申请国别(地区):

GB

年份:

2018

代理人:

摘要：

A method for the preparation of ibrutinib's precursor, 3-(4-phenoxyphenyl)-1-((3R)-piperidin-3-il)-1H-pyrazolof [3,4-d]pyrimidin-4-amine, involving arylation of N-protected 1-(piperidin-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine in the presence of palladium catalyst, nitrogen-containing ligand, and base, with subsequent removal of the protecting groups by known methods, is reported. (Formula (II))

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/