The present invention relates to a pharmaceutical composition for the treatment of diseases which involve cell proliferation. The invention also relates to a method for the treatment of said diseases, comprising co-administration of a compound 1 of Formula (I) wherein the groups L, R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in the claims and specification, optionally in form of its tautomers, racemates, enantiomers, diastereomers and the mixtures thereof and optionally in form of the pharmacologically acceptable acid addition salts, solvates, hydrates, polymorphs, physiologically functional derivatives or prodrugs thereof and of an effective amount of an active compound 2 and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of a compound 1 of Formula (I) and of an effective amount of an active compound 2 and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.本發明係關於一種用於治療關於細胞增生疾病之醫藥組合物。本發明亦關於一種用於治療該疾病之方法，包括共同投與式(I)之化合物1其中該基團L、R1、R2、R3、R4及R5具有如申請專利範圍及說明書所給之定義，視需要可為其互變異構體、外消旋物、對映異構物、非對映異構物及其混合物之形式及藥理上可接受酸加成鹽類、溶劑化物、水合物、多形體、生理功能性衍生物或其前藥之形式，及有效量之活性化合物2，及/或以放射療法共同治療，其比例可產生相加及協同作用，及關於式(I)之化合物1及其有效量之活性化合物2及/或放射療法於製造對應醫藥組合製備物之組合用途。
